- Fairfield Inn & Suites Santee9.3Santee
- Holiday Inn Express & Suites Orangeburg by IHG8.3Orangeburg
- Baymont Inn & Suites7.3Manning
- Sleep Inn Orangeburg7.8Orangeburg
- Comfort Inn & Suites Santee I-957.6Santee
- Winton Inn & SuitesBarnwell5.2
- Hampton Inn & Suites Orangeburg, SC8.8Orangeburg
- Days Inn by Wyndham Orangeburg South5.3Orangeburg
- Days Inn by Wyndham Orangeburg5.2Orangeburg
- Days Inn by Wyndham St George7.1Saint George
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